NOVEL THERAPEUTIC STRATEGIES TARGETING MYELOID-DERIVED SUPPRESSOR CELL IMMUNOSUPPRESSIVE MECHANISMS FOR CANCER TREATMENT

Novel therapeutic strategies targeting myeloid-derived suppressor cell immunosuppressive mechanisms for cancer treatment

Cancer is the leading cause of death globally superseded only by cardiovascular diseases, and novel strategies to overcome therapeutic resistance against existing cancer treatments are urgently required.Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells with potent immunosuppressive capacity against well-established anti-tumour eff

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Generation of Human Neutrophils from Induced Pluripotent Stem Cells in Chemically Defined Conditions Using ETV2 Modified mRNA

Summary: This protocol describes a rapid and efficient feeder-, serum-, and xeno-free method for neutrophil generation from hiPSCs using ETV2 modified Trucks mRNA (mmRNA), which directs hematoendothelial programming of hiPSCs.Hematoendothelial progenitors were cultured with GM-CSF, FGF-2, and UM171 to expand myelomonocytic progenitors, followed by

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Internet of Spacecraft for Multi-Planetary Defense and Prosperity

Recent years have seen unprecedentedly fast-growing prosperity in the commercial space industry.Several privately funded aerospace manufacturers, such as Space Exploration Technologies Corporation (SpaceX) and Blue Origin have transformed what we used to know about this capital-intense industry and gradually reshaped the future of human civilizatio

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